A meta-analysis of 163 studies and 48,841 people found both Prolonged Exposure and Cognitive Processing Therapy produced large PTSD symptom reductions (Hedges' g = 1.67), but no patient characteristic predicted which therapy worked better until ten unusual studies were removed.
A Journal-Style Digest of Clinical Research
Making clinical research legible, one study at a time.
The Clinical Perspective distills published research in clinical psychology and mental health into clear, accurate, and accessible summaries. Browse the latest posts, follow every study back to its original source, and help decide what gets covered next — suggest a study or upvote others' picks in the Reader Queue.
Latest Research
The most recent studies covered, each summarized in plain English and linked back to the original paper. Tap any entry to read the full summary.
Scans of 449 people with bipolar disorder and 510 controls across 16 sites found less efficient, more roundabout brain wiring in emotion and reward circuits, with the disruption tracking illness duration and severity.
Researchers compared 346 people hospitalized continuously for at least five years with treatment-resistant schizophrenia against more than 18,000 others. Each standard-deviation rise in schizophrenia polygenic score raised the odds of being in that most severe group by 40% to 80%.
A 931-person validation of the Polish Short Dark Tetrad found the sadism and psychopathy scales performed well, but the Machiavellianism subscale showed weak internal reliability (alpha = .67).
181 adults with PTSD linked to childhood interpersonal trauma tried an online program combining self-guided modules with optional virtual group sessions. It beat standard care on symptom reduction, with benefits still holding four months later.
Researchers measured organophosphate pesticide breakdown products in the urine of 3,339 pregnant women across 20 US sites and later scored their children's autism-related traits. After full adjustment, prenatal exposure showed no association with those traits.
Researchers tracked about 9,000 families in the Norwegian Mother, Father, and Child Study and compared cousins to strip out shared family background. Small links between parents' psychiatric symptoms and children's 5th-grade test scores disappeared once cousins were compared.
A meta-analysis pooled 37 studies covering 648,626 antidepressant-exposed pregnancies and 24,967,806 unexposed ones. Raw estimates showed 35% higher ADHD risk and 69% higher autism risk in exposed children, but the associations shrank or disappeared once confounding was accounted for, and fathers' antidepressant use during pregnancy showed a similar pattern.
In a phase 2b trial across 16 European sites, 81 adults with treatment-resistant depression received up to three escalating inhaled doses of mebufotenin (GH001) or placebo on a single day. One week later, 57.5% of the drug group (23 of 40) were in remission, compared with 0% of the 41 placebo patients.
About The Clinical Perspective
The Clinical Perspective exists to close the gap between published clinical research and the people it affects. Each post distills a study — its methods, findings, and limitations — into a summary that is rigorous enough for clinicians and clear enough for anyone else.
This site serves as a standing archive of that work: a place to browse past coverage, verify sources against the original posts, and get in touch about new research worth covering.
Read more — our mission, how studies are chosen, and our editorial principles →
Submit Your Research
Researchers, clinicians, and authors are welcome to submit published or in-press work for consideration. Priority is given to peer-reviewed studies with clear clinical or public health relevance.
1
Prepare your materials
A link or PDF of the paper (or preprint), plus 2–3 sentences on why it matters clinically.
2
Reach out
Send it by email or Instagram DM using the links below. Include your name, affiliation, and role on the paper, if any.
3
Hear back
Submissions are reviewed on a rolling basis. Not every submission is covered, but every submission is read.